Masaki Otagiri Selected Research

Hemoglobins (Hemoglobin)

12/2021	Liposomal Artificial Red Blood Cell-Based Carbon Monoxide Donor Is a Potent Renoprotectant against Cisplatin-Induced Acute Kidney Injury.
10/2020	Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles.
11/2018	Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity.
1/2016	Long-Term Stored Hemoglobin-Vesicles, a Cellular Type of Hemoglobin-Based Oxygen Carrier, Has Resuscitative Effects Comparable to That for Fresh Red Blood Cells in a Rat Model with Massive Hemorrhage without Post-Transfusion Lung Injury.
1/2016	Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties.
10/2015	Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model.
8/2014	Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced pulmonary fibrosis.
8/2012	α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
4/2011	Fluid resuscitation with hemoglobin vesicles prevents Escherichia coli growth via complement activation in a hemorrhagic shock rat model.
3/2011	Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.

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Masaki Otagiri Research Topics

Disease

24	Neoplasms (Cancer) 03/2022 - 05/2002
16	Chronic Renal Insufficiency 01/2022 - 04/2011
13	Inflammation (Inflammations) 03/2021 - 06/2007
11	Chronic Kidney Failure (Chronic Renal Failure) 11/2021 - 05/2002
10	Hemorrhage 01/2021 - 04/2011
8	Fibrosis (Cirrhosis) 01/2022 - 12/2008
8	Renal Insufficiency (Renal Failure) 11/2021 - 08/2004
8	Hemorrhagic Shock 11/2020 - 06/2009
6	Hypoxia (Hypoxemia) 01/2022 - 02/2015
6	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 03/2014
6	Infections 01/2021 - 01/2013
6	Ischemia 10/2015 - 03/2007
6	Uremia 09/2009 - 05/2002
5	Lung Injury 11/2020 - 09/2011
5	Reperfusion Injury 11/2020 - 07/2010
5	Wounds and Injuries (Trauma) 01/2020 - 02/2015
5	Anemia 01/2018 - 08/2004
4	Pancreatic Neoplasms (Pancreatic Cancer) 03/2022 - 09/2017
4	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020 - 11/2010
4	Secondary Hyperparathyroidism 01/2020 - 04/2011
3	Poisoning 01/2022 - 10/2021
3	Alcoholic Fatty Liver 03/2021 - 01/2020
3	Hypertension (High Blood Pressure) 02/2019 - 12/2009
3	Hepatitis 11/2018 - 04/2014
3	Atrophy 10/2017 - 02/2002
3	Thrombocytopenia (Thrombopenia) 11/2015 - 10/2013
3	Hypoalbuminemia 02/2015 - 05/2006
3	Polyneuropathies (Polyneuropathy) 12/2013 - 08/2005
3	Sepsis (Septicemia) 01/2013 - 04/2011
3	Drug Overdose 10/2005 - 06/2002
2	Fatty Liver 01/2022 - 03/2021
2	Stroke (Strokes) 03/2021 - 12/2020
2	Chronic Disease (Chronic Diseases) 02/2021 - 01/2014
2	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2018
2	Rhabdomyolysis 01/2020 - 09/2015
2	Shock 01/2020 - 10/2010
2	Chronic Hepatitis B 01/2020 - 06/2018

Drug/Important Bio-Agent (IBA)

25	AlbuminsIBA 01/2021 - 05/2002
21	Pharmaceutical PreparationsIBA 12/2021 - 05/2002
18	Human Serum Albumin FDA LinkGeneric 08/2021 - 12/2008
18	Proteins (Proteins, Gene)FDA Link 11/2020 - 08/2005
14	human S-nitrosoalbuminIBA 01/2020 - 12/2008
13	Therapeutic UsesIBA 01/2022 - 05/2013
12	Hemoglobins (Hemoglobin)IBA 12/2021 - 06/2009
11	Carbon MonoxideIBA 01/2022 - 01/2013
11	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 07/2007
10	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2022 - 08/2005
9	Liposomes (Liposome)IBA 12/2021 - 03/2011
9	AntioxidantsIBA 01/2018 - 04/2011
9	Uremic ToxinsIBA 01/2016 - 05/2002
8	Biological ProductsIBA 11/2020 - 12/2007
7	IndicanIBA 10/2017 - 05/2002
7	CytokinesIBA 01/2016 - 09/2011
6	ThioredoxinsIBA 11/2020 - 09/2011
5	ChitosanIBA 02/2021 - 06/2012
5	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 11/2020 - 01/2013
5	Oxygen (Dioxygen)IBA 01/2016 - 06/2009
4	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2021 - 04/2005
4	Antineoplastic Agents (Antineoplastics)IBA 08/2021 - 07/2014
4	Sulfates (Sulfates, Inorganic)IBA 02/2015 - 01/2010
4	Glycoproteins (Glycoprotein)IBA 08/2013 - 07/2007
4	Advanced Glycation End ProductsIBA 04/2011 - 04/2007
3	Cyanides (Isocyanides)IBA 01/2022 - 10/2021
3	MethemoglobinIBA 01/2022 - 10/2021
3	AntidotesIBA 01/2022 - 10/2021
3	SuspensionsIBA 12/2021 - 01/2013
3	Blood Proteins (Serum Proteins)IBA 11/2021 - 04/2009
3	NucleosidesIBA 05/2021 - 06/2018
3	4'-cyano-2'-deoxyguanosineIBA 05/2021 - 06/2018
3	BenzbromaroneIBA 01/2021 - 01/2015
3	ChitinIBA 12/2020 - 09/2016
3	Ether (Diethyl Ether)IBA 02/2019 - 09/2016
3	CyclodextrinsIBA 02/2019 - 09/2016
3	Immunoglobulin M (IgM)IBA 09/2015 - 03/2011
3	Adenosine Diphosphate (ADP)IBA 09/2015 - 08/2013
3	Fibrinogen (Factor I)FDA Link 09/2015 - 08/2013
3	Acetaminophen (Paracetamol)FDA LinkGeneric 02/2015 - 12/2012
3	Hydroxyl RadicalIBA 01/2015 - 10/2008
3	Prealbumin (Transthyretin)IBA 12/2013 - 08/2005
3	Amyloid (Amyloid Fibrils)IBA 12/2013 - 08/2005
3	Serum AlbuminIBA 09/2009 - 08/2008
3	hippuric acidIBA 02/2006 - 04/2005
2	Hypoglycemic Agents (Hypoglycemics)IBA 03/2022 - 02/2015
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2022 - 10/2021
2	Polysaccharides (Glycans)IBA 01/2022 - 03/2021
2	sacranIBA 01/2022 - 03/2021
2	Cisplatin (Platino)FDA LinkGeneric 12/2021 - 03/2014
2	Aripiprazole (Abilify)FDA Link 11/2021 - 10/2018
2	Drug CarriersIBA 08/2021 - 12/2010
2	TabletsIBA 02/2021 - 02/2019
2	CytochromesIBA 10/2020 - 01/2013
2	mannose-bovine serum albumin conjugateIBA 01/2020 - 02/2015
2	Concanavalin AIBA 01/2020 - 11/2018
2	Antiviral Agents (Antivirals)IBA 01/2020 - 06/2018
2	Cinacalcet (Sensipar)FDA Link 01/2020 - 01/2017

Therapy/Procedure

18	Therapeutics 10/2021 - 08/2007
15	Renal Dialysis (Hemodialysis) 01/2021 - 08/2004
9	Resuscitation 11/2020 - 06/2009
2	Nephrectomy 01/2022 - 10/2016
2	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2022 - 01/2020